GSTM1andGSTP1and respiratory health in asthmatic children exposed to ozone

Authors:
  • MRM. Ramirez-Aguilar
    M. Ramirez-Aguilar
  • JSJ. J. Sienra-Monge
    J. J. Sienra-Monge
  • HMH. Moreno-Macías
    H. Moreno-Macías
  • BRB. E. del Rio-Navarro
    B. E. del Rio-Navarro
  • GDG. David
    G. David
  • JMJ. Marzec
    J. Marzec
  • MHM. Hernández-Avila
    M. Hernández-Avila
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Abstract
Acute exposure to ozone has been related to a wide spectrum of health effects in susceptible individuals. Genetic factors may influence interindividual variation in ozone response. The current authors investigated the relationships between common polymorphisms in two genes involved in response to oxidative stress,i.e.glutathioneS-transferases M1 (GSTM1) and P1 (GSTP1), and both respiratory symptoms and lung function in response to ozone among childhood asthmatics.A total of 151 asthmatic children, who were participants in a randomised controlled trial of antioxidant vitamin supplementation in Mexico City, were studied. Children were genotyped using PCR methods and followed from October 1998–April 2000.Increases in reported breathing difficulty were associated with ozone exposure in children withGSTM1null (8%, 95% confidence interval (CI) 1–15%, per 20-ppb increase in 1-h maximum daily average over 7 days) orGSTP1Valine/Valine (Val/Val) genotypes (14%, 95% CI 5–25%). In children with bothGSTM1null andGSTP1Val/Val genotypes, the increase in breathing difficulty associated with a 20-ppb increase in ozone exposure was even greater (21%, 95% CI 5–39%).GSTP1genotypes were not significantly associated with ozone-related lung function changes.In conclusion, asthmatic children with glutathioneS-transferase M1 null and glutathioneS-transferase P1 Valine/Valine genotypes appear more susceptible to developing respiratory symptoms related to ozone exposure.

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