The biosynthesis of citrinin by Penicillium citrinum

Authors:
  • JBJill Barber
    Jill Barber
  • RCRachel H. Carter
    Rachel H. Carter
  • MGMary J. Garson
    Mary J. Garson
  • JSJames Staunton
    James Staunton
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Abstract
Incorporation studies have been carried out with [Me-13C]methionine and aromatic compounds labelled with 14C or 2H. Evidence is presented that 4,6-dihydroxy-3,5-dimethyl-2-(1-methyl-2-oxopropyl)benzaldehyde (13) is the first enzyme-free aromatic intermediate in the biosynthesis of citrinin in P. citrinum, and that all three methylations take place on the polyketide synthetase complex.