Ketamine for treatment of catheter related bladder discomfort: a prospective, randomized, placebo controlled and double blind study

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Abstract
Background. Intraoperative urinary catheterization might cause postoperative catheter related bladder discomfort (CRBD). We evaluated the efficacy of ketamine as a treatment modality for CRBD. Methods. Fifty-four, ASA physical status I and II, male and female adult patients, having CRBD after elective percutaneous nephrolithotomy were randomized into two equal groups of 27 each. In the postoperative period, patients who complained of CRBD received medication depending upon group allocation. Group 1 (Control) received placebo, Group II (Ketamine) received i.v. ketamine 250 µg kg−1. After induction of anaesthesia patients were catheterized with a 16 Fr Foley's catheter and the balloon was inflated with 10 ml distilled water. Grading of CRBD was done as none, mild, moderate and severe by a blinded observer at 0, 1, 2 and 6 h after operation. Results. Ketamine reduced the incidence of CRBD (PPPConclusion. I.V. ketamine (250 µg kg−1) is an effective treatment for reducing the incidence and severity of postoperative CRBD.

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