Transient, Severe Periventricular Hypodensity After Leukemic Prophylaxis with Cranial Irradiation and Intrathecal Methotrexate

Authors:
  • LWLyle R. Wendling
    Lyle R. Wendling
  • WBWerner A. Bleyer
    Werner A. Bleyer
  • GCGiovanni Di Chiro
    Giovanni Di Chiro
  • SMSamuel K. McIlvanie
    Samuel K. McIlvanie
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Abstract
Serial computed tomography (CT) demonstrated complete resolution of severe periventricular hypodensity occurring in a child after receiving prophylaxis for acute lymphocytic leukemia. The resolution of this encephalopathy suggests that early changes of subacute necrotizing leukoencephalopathy are reversible and CT is copable of detecting these early changes.