Pertussis toxin inhibits the angiotensin II and serotonin‐induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta

Authors:
  • CBChristian Bruns
    Christian Bruns
  • DMDieter Marmé
    Dieter Marmé
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Abstract
Angiotensin II, serotonin and K+‐depolarization cause an increase in free cytoplasmic Ca2+ in cultured smooth muscle cells. The involvement of a guanine nucleotide‐binding protein has been investigated by using pertussis toxin. When smooth muscle cells were pretreated with pertussis toxin angiotensin II and serotonin‐induced rise of cytosolic Ca2+ was found to be significantly reduced whereas the Ca2+ influx mediated by K+‐depolarization remained unchanged. These results suggest the participation of a guanine nucleotide‐binding protein in the receptor‐mediated rise of intracellular Ca2+.

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