Preparation and Characterization of Solid Dispersions of Piroxicam with Hydrophilic Carriers
Authors:
- Hadi ValizadehHadi Valizadeh
- Parvin Zakeri-MilaniPZParvin Zakeri-Milani
- Mohammad Barzegar-JalaliMohammad Barzegar-Jalali
- Ghobad MohammadiGMGhobad Mohammadi
- Mohammad-Ali Danesh-BahreiniMDMohammad-Ali Danesh-Bahreini
- Khosro AdibkiaKhosro Adibkia
- Ali NokhodchiAli Nokhodchi
- 1 January 2007
- journal article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 33 (1) , 45-56
Abstract
The objective of this study was to improve the dissolution rate of a poor water soluble drug, piroxicam, by solid dispersion technique. Solid dispersions were prepared by three different methods depending on the type of carrier. The dissolution rate of piroxicam was markedly increased in solid dispersion of myrj 52, Eudragit® E100 and mannitol. Solubility studies revealed a marked increase in the solubility of piroxicam with an increase in myrj 52 and Eudragit® E100 concentrations. Data from the X-ray diffraction and FT-IR spectroscopy showed that piroxicam was amorphous in the solid dispersions prepared with dextrin and Eudragit® E100.Keywords
This publication has 25 references indexed in Scilit:
- Physicochemical Characterization of Solid Dispersions of Indomethacin with PEG 6000, Myrj 52, Lactose, Sorbitol, Dextrin, and Eudragit® E100Drug Development and Industrial Pharmacy, 2004
- Improving drug solubility for oral delivery using solid dispersionsEuropean Journal of Pharmaceutics and Biopharmaceutics, 2000
- Physical characterization and optimisation of dissolution parameters of prochlorperazine maleate coevaporatesInternational Journal of Pharmaceutics, 1998
- Dissolution mechanism and rate of solid dispersion particles of nilvadipine with hydroxypropylmethylcelluloseInternational Journal of Pharmaceutics, 1997
- Physicochemical Characterizations of Piroxicam-Poloxamer Solid DispersionPharmaceutical Development and Technology, 1997
- Characteristics and Significance of the Amorphous State in Pharmaceutical SystemsJournal of Pharmaceutical Sciences, 1997
- Inhibition of indomethacin crystallization in poly(vinylpyrrolidone) coprecipitatesJournal of Pharmaceutical Sciences, 1995
- Enhancement of dissolution rate of nifedipine using sucrose ester coprecipitatesInternational Journal of Pharmaceutics, 1993
- A New Approach for Controlling the Release Rate of Pheniramine Aminosalicylate Via Solid Dispersion in Different Types of EudragitDrug Development and Industrial Pharmacy, 1984
- Dissolution Rates of High Energy Sulfathiazole‐Povidone Coprecipitates II: Characterization of Form of Drug Controlling Its Dissolution Rate via Solubility StudiesJournal of Pharmaceutical Sciences, 1976