To determine the survey-related experiential and attitudinal correlates of future health-related survey participation. From July 21, 2005, through October 25, 2005, we conducted a mixed-mode mail and telephone survey of 1636 noninstitutionalized Minnesota residents aged 18 years or older. The overall response rate was 49%. We examined the unadjusted effect of each independent variable on the likelihood of future participation in health-related surveys using univariate logistic regression and discerned the relative contribution of the different variables with multivariate logistic regression analysis. Respondents were asked to complete an average of 4.5 different surveys in the year before the current survey; approximately a quarter of the respondents perceived these surveys to be burdensome. The likelihood of future participation in health-related surveys was negatively related to good health status, a busy schedule, and perceptions that the surveys were too long. Respondents were more than twice as likely to indicate that they would participate in a future health-related survey if they knew the organization doing the survey. For health-related surveys, investigators should remain mindful of people's busy schedules and keep their surveys as short as possible. Further research is needed to clarify whether the decision to participate in a survey hinges more on knowing the organization paying to have a survey performed (the sponsor) or the survey vendor collecting the data.