Structural and Biochemical Basis for Development of Diketo Acid Inhibitors Targeting the Cap-Snatching Endonuclease of the Ebinur Lake Virus (Order: Bunyavirales )

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Abstract
The Bunyavirales contain many important human pathogens such as Crimean-Congo hemorrhagic fever virus and Lassa virus that pose serious threats to public health; however, currently there are no specific antiviral drugs against these viruses. The diketo acid inhibitor L-742,001 is a potential drug as it inactivates the cap-snatching endonuclease (EN) encoded by bunyaviruses.
Funding Information
  • China Postdoctoral Science Foundation (2018M632827)
  • Ministry of Science and Technology of the People's Republic of China (2018YFA0507203, 2018YFA0507200)
  • Hubei Natural Science Foundation for Distinguished Young Scholar (2021CFA050)
  • Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory, Chinese Academy of Sciences (2020-NBL-ZD-00030, 2018ACCP-ZD02, 2021ACCP-MS10)
  • Open Research Fund Program of the State Key Laboratory of Virology of China (2020IOV003)
  • Key Biosafety Science and Technology Program of Hubei Jiangxia Laboratory (JXBS001)

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