Compounded hormonal pellets: a critical review of current evidence and risks
Authors:
- Maria Celeste Osório WenderMWMaria Celeste Osório Wender
- Marcelo Luis SteinerMSMarcelo Luis Steiner
- César Eduardo FernandesCFCésar Eduardo Fernandes
- Lia Cruz Vaz da Costa DamásioLDLia Cruz Vaz da Costa Damásio
- José Maria Soares JúniorJJJosé Maria Soares Júnior
- Lúcia Helena Simões da Costa PaivaLPLúcia Helena Simões da Costa Paiva
- Ilza Maria Urbano MonteiroIMIlza Maria Urbano Monteiro
- Ricardo de Almeida QuintairosRQRicardo de Almeida Quintairos
- Clayton Luiz Dornelles MacedoCMClayton Luiz Dornelles Macedo
- Agnaldo Lopes da Silva FilhoAFAgnaldo Lopes da Silva Filho
Open Access
- 1 January 2025
- journal article
- review article
- Published by FapUNIFESP (SciELO) in Revista da Associação Médica Brasileira
- Vol. 71 (7) , e20250121
Abstract
The use of compounded hormonal pellets has recently gained popularity in Brazil, driven by claims of benefits beyond their intended clinical indications, such as enhanced muscle mass, improved physical and sexual performance, and overall well-being. However, this growing trend raises significant concerns within the medical community due to the lack of robust scientific evidence supporting their safety and efficacy in the treatment of gynecological conditions, as well as insufficient regulatory oversight.Keywords
This publication has 33 references indexed in Scilit:
- The effect of oophorectomy and hormone replacement on neurohypophyseal hormone secretion in womenClinical Endocrinology, 1996
- Sustained-release estradiol implants and a levonorgestrel-releasing intrauterine device in hormone replacement therapyAmerican Journal of Obstetrics and Gynecology, 1995
- Clinical trial with Nestorone™ subdermal contraceptive implantsContraception, 1995
- Postmenopausal oestrogen replacement therapy with subcutaneous oestradiol implantsMaturitas, 1993
- A randomized comparison of nonoral estradiol delivery in postmenopausal womenAmerican Journal of Obstetrics and Gynecology, 1988
- SUBCUTANEOUS HORMONE IMPLANTS FOR THE CONTROL OF CLIMACTERIC SYMPTOMSThe Lancet, 1984
- Comparative clinical trial of the progestins R-2323 and levonorgestrel administered by subdermal implantsContraception, 1978
- Clinical trial with subdermal implants of the progestin R-2323Contraception, 1977
- FERTILITY-CONTROL WITH SUB-DERMAL SILASTIC CAPSULES CONTAINING A NEW PROGESTIN (ST-1435)1976
- Contraceptive effectiveness of silasticContraception, 1975