Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis

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Abstract
Objective: The risk of rheumatoid arthritis (RA) is increased in the offspring of individuals affected with various autoimmune disorders, including psoriasis. Recently, the deletion of 2 genes from the late cornified envelope (LCE) gene cluster, LCE3C and LCE3B, has been associated with psoriasis in several populations. The purpose of this study was to assess whether this polymorphic gene deletion could also be involved in susceptibility to RA.Methods: We tested for association between the LCE3C_LCE3B copy number variant and a single‐nucleotide polymorphism in strong linkage disequilibrium with this variant (rs4112788) and RA in 2 independent case–control data sets (197 and 400 samples from patients with RA, respectively, and 411 and 567 samples from control subjects, respectively), collected at 4 Spanish hospitals. All samples were directly typed for presence of the LCE3C_LCE3B deletion (LCE3C_LCE3B‐del) by polymerase chain reaction, and association analysis was performed using the SNPassoc R package.Results: An association of homozygosity for the LCE3C_LCE3B‐del and rs4112788 C allele with the risk of RA was observed in the first data set and was replicated in an independent case–control set. A combined analysis showed an overall P value of 0.0012 (odds ratio [OR] 1.45, 95% confidence interval [95% CI] 1.16–1.81) for association of the LCE3C_LCE3B‐del. When the analysis was stratified for serologic data, we observed association in anti–cyclic citrullinated peptide (anti‐CCP)–positive patients (P = 0.012, OR 1.51 [95% CI 1.09–2.13]) but not in anti‐CCP–negative patients.Conclusion: We have identified an association between the LCE3C_LCE3B‐del and RA, and we have verified a pleiotropic effect of a common genetic risk factor (LCE3C_LCE3B‐del) for autoimmune diseases that is involved in both psoriasis and RA.

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