Oxcarbazepine Does Not Affect the Anticoagulant Activity of Warfarin
Authors:
Abstract
Summary: The possible interaction of the antiepileptic drug oxcarbazepine (OCBZ) on the anticoagulant effect of warfarin was investigated in 10 healthy male volunteers. After reaching steady‐state conditions by repeated administration of warfarin, the prothrombin time (Quick value) was assessed before and after single (600 mg) and multiple dosing (450 mg twice daily in 1 week) of OCBZ. In 7 of the 10 volunteers with evaluable data, the prothrombin time was not significantly different (paired t test) from baseline either after single (p = 0.299) or repeated dosing (p = 0.333), indicating that OCBZ does not interact to any relevant extent with the hypothrombinemic effect of warfarin.Keywords
This publication has 10 references indexed in Scilit:
- A double-blind study comparing oxcarbazepine and carbamazepine in patients with newly diagnosed, previously untreated epilepsyEpilepsy Research, 1989
- Oxcarbazepine (GP 47.680): A Possible Alternative to Carbamazepine?Epilepsia, 1987
- Comparison of oxcarbazepine and carbamazepine: a double-blind studyEpilepsy Research, 1987
- The metabolism of14C-oxcarbazepine in manXenobiotica, 1986
- Reductases for carbonyl compounds in human liverBiochemical Pharmacology, 1985
- Clinical Implications of Enzyme Induction and Enzyme InhibitionClinical Pharmacokinetics, 1981
- Interaction between carbamazepine and warfarin.BMJ, 1980
- The expanding role of microsomal enzyme induction, and its implications for clinical chemistry.Clinical Chemistry, 1980
- Cytoplasmic Aldo-Keto Reductases: A Class of Drug Metabolizing EnzymesScience, 1976
- Carbamazepine‐induced acceleration of diphenylhydantoin and warfarin metabolism in manClinical Pharmacology & Therapeutics, 1971