Tenascin-C Levels in the Vitreous of Patients with Proliferative Vitreoretinopathy
Authors:
- Yoshinori MitamuraYMYoshinori Mitamura
- Shinobu TakeuchiSTShinobu Takeuchi
- Kenji OhtsukaKOKenji Ohtsuka
- Akira MatsudaAMAkira Matsuda
- Teiko YamamotoTYTeiko Yamamoto
- Shuichi YamamotoSYShuichi Yamamoto
- Noriko HiraiwaNHNoriko Hiraiwa
- Moriaki KusakabeMKMoriaki Kusakabe
- 30 October 2003
- journal article
- research article
- Published by S. Karger AG in Ophthalmologica
- Vol. 217 (6) , 422-425
Abstract
Purpose: To determine whether tenascin-C levels are elevated in the vitreous of patients with proliferative vitreoretinopathy (PVR). Methods: We assayed tenascin-C levels in vitreous samples of 110 consecutive patients with PVR (30 eyes), rhegmatogenous retinal detachment (RRD; 32 eyes), and macular hole or idiopathic epiretinal membrane (controls, 48 eyes) using an enzyme-linked immunosorbent assay. Results: Vitreous levels of tenascin-C (median [range]) were significantly greater in PVR (845.0 ng/ml [411.0–1,050.0]) than in RRD (21.9 ng/ml [13.2–127.0]) and in the controls (18.0 ng/ml [9.9–199.0]) (p < 0.0001). Conclusion: The results indicate the possibility that tenascin-C is involved in the pathogenesis of PVR.Keywords
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