Supplementary Figure S3 shows, for each graph, the effect estimate and the 95% CI plotted across all 33 CpG sites in the AHRR gene. Multivariable models included adjustment for age, phase of blood sampling, education level, ethnicity, and smoking (CSI - cumulative smoking index). The interpretation of the effect estimate is the difference in mean methylation level relative to those never exposed to each agent (reference group). Categorization of occupational exposures was based on the FWI as never exposed (FWI=0, reference group), Low exposure (>0 and lower than the population median, in blue square) and High exposure (≥population median, in red triangle). * Denotes a p-value < 0.05.