Abolition of Long-Term Stability of New Hippocampal Place Cell Maps by NMDA Receptor Blockade
- 26 June 1998
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 280 (5372) , 2121-2126
Abstract
Hippocampal pyramidal cells are called place cells because each cell tends to fire only when the animal is in a particular part of the environment—the cell's firing field. Acute pharmacological blockade of N -methyl- d -aspartate (NMDA) glutamate receptors was used to investigate how NMDA-based synaptic plasticity participates in the formation and maintenance of the firing fields. The results suggest that the formation and short-term stability of firing fields in a new environment involve plasticity that is independent of NMDA receptor activation. By contrast, the long-term stabilization of newly established firing fields required normal NMDA receptor function and, therefore, may be related to other NMDA-dependent processes such as long-term potentiation and spatial learning.Keywords
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