INCREASE IN RAT BRAIN TYROSINE HYDROXYLASE ACTIVITY PRODUCED BY ELECTROCONVULSIVE SHOCK
Authors:
- 1 August 1969
- journal article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 63 (4) , 1117-1119
Abstract
A sustained increase in the turnover of norepinephrine coupled with an increased concentration of that amine has, in a previous study, been observed in the brains of rats exposed to electroconvulsive shock twice daily for one week. The phenomenon has been further examined by studying the effects of a similar regimen of electroconvulsive shock upon tyrosine hydroxylase in the brain, since that enzyme appears to be rate-limiting in norepinephrine synthesis. A small (15%) but significant increase in the whole brain enzyme activity was found in the electroshock-treated animals. A significant increase of tyrosine hydroxylase activity was found in the brainstem (24%) and cortex (20%) of such animals.Keywords
This publication has 4 references indexed in Scilit:
- THE REGULATION OF NOREPINEPHRINE SYNTHESIS. EFFECT OF PUROMYCIN ON THE ACCELERATED SYNTHESIS OF NOREPINEPHRINE ASSOCIATED WITH NERVE STIMULATIONThe Journal of Pharmacology and Experimental Therapeutics, 1968
- EFFECTS OF STRESS ON THE METABOLISM OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN IN THE CENTRAL NERVOUS SYSTEM OF THE RAT. I. MODIFICATIONS OF NOREPINEPHRINE TURNOVERThe Journal of Pharmacology and Experimental Therapeutics, 1968
- A sustained effect of electroconvulsive shock on the turnover of norepinephrine in the central nervous system of the rat.Proceedings of the National Academy of Sciences, 1967
- A rapid and simple radioassay for tyrosine hydroxylase activityAnalytical Biochemistry, 1964