Folliculitis Induced by Actinomycin D

Authors:
  • EEErvin H. Epstein
    Ervin H. Epstein
  • MLMarvin A. Lutzner
    Marvin A. Lutzner
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Abstract
In nine of 11 adult patients treated with actinomycin D a characteristic skin eruption developed, with predictable progression from erythema to papules and pustules and from face to trunk. The dominant histologic feature of these lesions was initial replacement of the hair follicles and sebaceous glands with neutrophils. After resolution of the inflammation, plugged, dilated follicles persisted for several months. Although often dramatic and unsightly, this eruption was benign and required no modification of treatment.

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