Demethylgorgosterol-derived steroids as a new class of RORγ-preferential inverse agonists
Open Access
- 8 October 2026
- journal article
- Published by Elsevier in European Journal of Medicinal Chemistry
- Vol. 321 (Pt 2) , 119391
Abstract
No abstract availableKeywords
Funding Information
- Deutsche Forschungsgemeinschaft (284178167)
- Deutsche Forschungsgemeinschaft (266379491)
This publication has 33 references indexed in Scilit:
- Formal Semisynthesis of Demethylgorgosterol Utilizing a Stereoselective Intermolecular Cyclopropanation ReactionEuropean Journal of Organic Chemistry, 2021
- Retinoic acid-related orphan receptor γ (RORγ): Connecting sterol metabolism to regulation of the immune system and autoimmune diseaseCurrent Opinion in Toxicology, 2018
- Digoxin: The good and the badTrends in Cardiovascular Medicine, 2016
- Enantioselective Cyclopropanation of a Wide Variety of Olefins Catalyzed by Ru(II)–Pheox ComplexesAccounts of Chemical Research, 2016
- Identification of Natural RORγ Ligands that Regulate the Development of Lymphoid CellsCell Metabolism, 2015
- Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptorSteroids, 2012
- Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear ReceptorsMolecular Cell, 2000
- A Regulatory Cascade of the Nuclear Receptors FXR, SHP-1, and LRH-1 Represses Bile Acid BiosynthesisMolecular Cell, 2000
- Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BARMolecular Cell, 1999
- ROR-γ: The Third Member of ROR/RZR Orphan Receptor Subfamily That Is Highly Expressed in Skeletal MuscleBiochemical and Biophysical Research Communications, 1994