Detection of glycosaminoglycan loss in articular cartilage by fluorescence lifetime imaging

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Articular cartilage is the near frictionless tissue at the end of long bones that allows smooth movement of joints and absorbs shock. Cartilage degenerative diseases such as osteoarthritis (OA) are major causes of disability worldwide1 and have a substantial contribution to healthcare cost.2 This large economic burden will continue to increase as the population ages. Clinical OA is a late-stage condition for which disease-modifying opportunities are limited. However, OA typically develops over decades, offering a long window of time to potentially alter its course. As such, characterization of pre- or early-OA disease states will be critical to support a paradigm shift from palliation of late disease toward prevention.3 Unfortunately, early diagnosis of OA is still a challenging, unmet clinical need that must be addressed.
Funding Information
  • California Institute for Regenerative Medicine (RT3-07981)

This publication has 34 references indexed in Scilit: