Binge Ethanol and Liver: New Molecular Developments
- 24 January 2013
- journal article
- review article
- Published by Wiley in Alcohol, Clinical and Experimental Research
- Vol. 37 (4) , 550-557
Abstract
Binge consumption of alcohol is an alarming global health problem. Binge (acute) ethanol (EtOH) is implicated in the pathophysiology of alcoholic liver disease (ALD). New studies from experimental animals and from humans indicate that bingeEtOHhas profound effects on immunological, signaling, and epigenetic parameters of the liver. This is in addition to the known metabolic effects of acuteEtOH. BingeEtOHalters the levels of several cellular components and dramatically amplifies liver injury in chronicallyEtOHexposed liver. These studies highlight the importance of molecular investigations into binge effects ofEtOHfor a better understanding ofALDand also to develop therapeutic strategies to control it. This review summarizes these recent developments.Keywords
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