Glycosylated Diarylmethyloxy-Triazines: Facile Synthesis and Aqueous Self-Assembly for Supramolecular Hydrogel Formation

Authors:
Publisher website
Google Scholar
Abstract
Glycosylated self-assembling molecules enable the construction of nanostructures whose surfaces are decorated with saccharides under aqueous conditions, reminiscent of biological systems at both the molecular and cellular levels. Such glyco-nanostructures thus hold great promise as soft materials for biological applications. Herein, we report the facile synthesis of glycosylated diarylmethyloxy-triazines, which serve as new building blocks for fabricating self-assembled nanostructures in aqueous media and forming supramolecular hydrogels. The triazine scaffold enables the protecting-group-free synthesis of glycosylated compounds with reasonable β-anomer selectivity. Notably, both the substituents on the aryl groups attached to the triazine core and the geometry of the glycosidic linkages in the disaccharides strongly influence the hydrogelation behavior.
Funding Information
  • Support for Pioneering Research Initiated by the Next Generation
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Society for the Promotion of Science (23H01815)
  • Japan Society for the Promotion of Science (24H01126)
  • Japan Society for the Promotion of Science (25K18078)
  • Tokai Pathways to Global Excellence

This publication has 39 references indexed in Scilit: