Regulation of Murine Dendritic Cell Immune Responses byHelicobacter felisAntigen

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Abstract
Helicobacterinfections are present in approximately 50% of humans, causing severe illnesses such as gastritis and malignancies. Dendritic cells (DC) are critical antigen-presenting cells which link innate and adaptive immune responses. The mechanism of dendritic cell regulation inHelicobacter-induced gastritis is poorly understood. These studies characterized DC isolated from the lamina propria ofHelicobacter-infected mice and analyzed innate and adaptive immune responses elicited byHelicobacterantigen (Ag)-pulsed DC. The presence of DC was elevated in the gastric lamina propria infiltrate of infected mice in comparison with controls. After treatment withHelicobacter felisAg, DC were polarized to secrete interleukin-6 as the dominant cytokine. In the presence of DC andHelicobacterAg, responder allogeneic T cells in culture exhibited limited cell division. We suggest that the response of DC and T cells toHelicobacterAg is critical to the chronic persistence ofHelicobacter-induced gastritis.

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