Synthesis and Structure–Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia
- 20 December 2017
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Medicinal Chemistry Letters
- Vol. 9 (1) , 61-64
Abstract
We report the first synthesis of the plant isoflavonoid biliatresone. The convergent synthesis has been applied to the synthesis of several analogs, which have facilitated the first structure–activity relationship study for this environmental toxin that, on ingestion, recapitulates the phenotype of biliary atresia.Keywords
Funding Information
- University of Pennsylvania
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK092111)
- Office of the Director (S10 OD011980)
- Mayo Foundation for Medical Education and Research (1KL2TR001879-01)
- Fred and Suzanne Biesecker Pediatric Liver Center, Children's Hospital of Philadelphia
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