Optimizing Preexposure Prophylaxis Adherence: Evaluating Point-of-Care Urine Tenofovir Testing and Tailored Counseling Among Young South African Women

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Abstract
Among South African women using oral HIV preexposure prophylaxis, we compared a urine tenofovir point-of-care test with dried blood spot tenofovir diphosphate concentrations for recent vs longer-term adherence and assessed acceptability. The test demonstrated 76% accuracy, 100% sensitivity, and 69% specificity for high adherence (tenofovir diphosphate ≥700 fmol/punch) and was highly acceptable. Clinical Trials Registration: NCT04038060.
Funding Information
  • National Institute of Mental Health
  • National Institutes of Health (R01MH114544)
  • National Institutes of Health (2R01AI143340)

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