Maintenance antipsychotic medication patterns in outpatient schizophrenia patients: a naturalistic cohort study
Authors:
- 31 August 2005
- journal article
- Published by Wiley in Acta Psychiatrica Scandinavica
- Vol. 113 (2) , 126-134
Abstract
Objective: Newer antipsychotics are increasingly used in schizophrenia maintenance. The UK change has been slow with little known on switching patterns. We aimed to investigate antipsychotic prescribing patterns in schizophrenia patients. Method: A naturalistic six‐site cohort sample of 600 patients were interviewed by researchers at 6‐monthly intervals for 2 years to record their clinical and social functioning; use of services and medication for the preceding 6 months was obtained by structured extraction from clinical case notes. Results: Alterations in antipsychotic medication were frequent in this group, mainly during periods of inpatient care. Atypical prescribing increased steadily, though slowly, across the period. Polypharmacy was less than anticipated. Conclusion: Inpatient care remains the main forum for switching of antipsychotics. The UK maintains a slow shift to atypical antipsychotics.Keywords
This publication has 12 references indexed in Scilit:
- The European Schizophrenia Outpatient Health Outcomes (SOHO) study: rationale, methods and recruitmentActa Psychiatrica Scandinavica, 2003
- Antipsychotic combination therapy in schizophrenia. A review of efficacy and risks of current combinationsActa Psychiatrica Scandinavica, 2002
- Heavy users of acute psychiatric beds: randomized controlled trial of enhanced community management in an outer London boroughPsychological Medicine, 2002
- Community mental health team case-loads and diagnostic case-mixPsychiatric Bulletin, 2000
- Homicides by people with mental illness: myth and realityThe British Journal of Psychiatry, 1999
- Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trialAmerican Journal of Psychiatry, 1997
- Guidelines for Neuroleptic Relapse Prevention in Schizophrenia: Towards a Consensus View1991
- The Vermont longitudinal study of persons with severe mental illness, II: Long-term outcome of subjects who retrospectively met DSM-III criteria for schizophreniaAmerican Journal of Psychiatry, 1987
- The Positive and Negative Syndrome Scale (PANSS) for SchizophreniaSchizophrenia Bulletin, 1987
- A New Depression Scale Designed to be Sensitive to ChangeThe British Journal of Psychiatry, 1979