Chronic Lymphocytic Leukaemia in 5 Siblings

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Abstract
In 5 siblings of a family comprising 7 siblings and 2 half sibs, chronic lymphocytic leukaemia was diagnosed. Since the occurrence of such families strongly suggest that a familial factor may play a role in the aetiology of chronic lymphocytic leukaemia, parameters of the immune system and several genetic markers were determined. In addition electron microscopy and chromosome studies of the lymphocytes were performed. However, so far no clue about the nature of such a familial factor could have been detected.

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