Regional heterogeneity and sex differences along the mouse aorta

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Abstract
We systematically assessed vasoreactivity of multiple aortic regions in male and female wild-type mice via wire myography. We observed regional and sex differences in vasoreactivity along the aorta, suggesting that the mouse aorta is heterogeneous and not a uniform conduit vessel for blood distribution. Notably, the infrarenal aorta was unique in its vasomotor responses. These data serve as a reference for assay design of aortic function in disease states and highlight region-specific sex differences.
Funding Information
  • National Heart, Lung, and Blood Institute (R01HL155618)
  • NIH Office of the Director (R21OD037867)
  • National Heart, Lung, and Blood Institute (R01HL168600)
  • Child Health Research Institute, University of Nebraska Medical Center (MD/PhD Collaborative Pilot Grant)

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