Crystallization Selectivity of Ribavirin Solution and Amorphous Phase

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Abstract
Crystallization selectivity is an important principle in polymorph control. Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin are prepared, and the short-range order similarities between these solid forms and ribavirin aqueous solution and DMSO solution are compared via mid-frequency Raman difference spectra (MFRDS). The crystallization process from amorphous ribavirin to Form I and from solution to amorphous phase is explained. Reasons for the difficulty in preparing the DMSO solvate are proposed. The rationale provided for the crystallization selectivity provides a foundation for the synthesis of metastable phases with a robust and convenient method.
Funding Information
  • National Natural Science Foundation of China (22005175, 2023J011024, 2022J011176, JAT220349, SKLPEE-KF202313, ZD1804)
  • the Provincial Natural Science Foundation of Fujian (22005175, 2023J011024, 2022J011176, JAT220349, SKLPEE-KF202313, ZD1804)
  • Education and Scientific Research on Young Teachers of Fujian (22005175, 2023J011024, 2022J011176, JAT220349, SKLPEE-KF202313, ZD1804)
  • the Open Project Program of the State Key Laboratory of Photocatalysis on Energy and Environment (22005175, 2023J011024, 2022J011176, JAT220349, SKLPEE-KF202313, ZD1804)
  • the Open Fund of Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization (22005175, 2023J011024, 2022J011176, JAT220349, SKLPEE-KF202313, ZD1804)

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