Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs
- 1 August 2017
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 61 (8)
Abstract
White and opaque cells of Candida albicans have the same genome but differ in gene expression patterns, metabolic profiles, and host niche preferences. We tested whether these differences (which include the differential expression of drug transporters) resulted in different sensitivities to 27 antifungal agents. The analysis was performed in two different strain backgrounds; although there was strain-to-strain variation, only terbinafine hydrochloride and caspofungin showed consistent, two-fold differences between white and opaque cells across both strains.Keywords
Funding Information
- HHS | National Institutes of Health (R01AI049187)
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