Neuropsychiatric manifestations of depression in multiple sclerosis: neuroinflammatory, neuroendocrine, and neurotrophic mechanisms in the pathogenesis of immune-mediated depression
Authors:
- Adam L. KaplinAKAdam L. Kaplin
- Kerr DAKDKerr DA
- Kaplin AiKAKaplin Ai
Open Access
- 30 June 2007
- journal article
- review article
- Published by Taylor & Francis in Dialogues in clinical neuroscience
- Vol. 9 (2) , 125-139
Abstract
Evidence suggests that depression in multiple sclerosis (MS) is largely biologically mediated by some of the same processes involved in the immunopathogenesis of this neurologic disease. In particular, the increase in proinflammatory cytokines, activation of the hypothalamic-pituitary-adrenal (HPA) …Keywords
This publication has 170 references indexed in Scilit:
- Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cellBiochemical and Biophysical Research Communications, 2006
- Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain MonoaminesCellular and Molecular Neurobiology, 2005
- Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclerosisBrain, 2004
- Long-term statin use and psychological well-beingJACC, 2003
- Neurobehavioral Effects of Interferon-α in Cancer Patients Phenomenology and Paroxetine Responsiveness of Symptom DimensionsNeuropsychopharmacology, 2002
- Cytokine Production and Treatment Response in Major Depressive DisorderNeuropsychopharmacology, 2000
- Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosisAnnals of Neurology, 2000
- Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remissionEuropean Archives of Psychiatry and Clinical Neuroscience, 1997
- The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated InflammationNew England Journal of Medicine, 1995
- STRUCTURAL BRAIN CORRELATES OF EMOTIONAL DISORDER IN MULTIPLE SCLEROSISBrain, 1986