Red blood cell adenine nucleotides abnormalities in down syndrome

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Abstract
The red blood cell adenine nucleotides of 20 Down Syndrome patients and 20 healthy controls were determined by a new high‐performance liquid chromatography method. All patients showed increased concentrations of adenosine 5′‐diphosphate (ADP) and adenosine 5′‐monophosphate (AMP), while adenosine 5′‐triphosphate (ATP), nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+) were within normal ranges. This alteration of the energetic charge could be partly responsible for the impairment of glucose metabolism in these patients.

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