Copper‐Catalyzed Alkynylation of C(sp3)−H Bonds in N‐Fluoro‐sulfonamides
Authors:
- 20 September 2019
- journal article
- research article
- Published by Wiley in Advanced Synthesis & Catalysis
- Vol. 361 (23) , 5478-5482
Abstract
Herein, we developed a copper‐catalyzed approach for the remote C(sp3)−H alkynylation of N‐fluoro‐sulfonamides. With Cu(OTf)2 as the catalyst, the carbon radical which generated from nitrogen radical‐mediated 1,5‐hydrogen atom transfer, go through an addition/fragmentation reaction with various acetylene sulfones. A variety of internal alkynes were synthesized in high yield and regioselectivity. Notably, celecoxib‐derived substrate can also gave the corresponding functionalized product in good yield under the standard conditions. magnified imageKeywords
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