Analysis of interleukin‐2 activity in patients with Behçet's disease. Ability of T cells to produce and respond to interleukin‐2

Authors:
Open Access
Publisher website
Google Scholar
Abstract
We examined interleukin‐2 (IL‐2) activity in patients with Behçet's disease. T cells from all patients with Behçet's disease were able to produce normal levels of IL‐2 in response to phytohemagglutinin; however, responsiveness to IL‐2 was impaired in their concanavalin A‐activated lymphoblasts. This defect was due to decreased numbers of cells bearing IL‐2 receptors in patients with early active disease; in patients with chronic active or with inactive disease, there was a decrease in density of IL‐2 receptors on T cells bearing these receptors. Unresponsiveness of T cells to IL‐2 may thus contribute to immunologic aberrations in Behçet's disease.

This publication has 18 references indexed in Scilit: