Objective: This study aimed to investigate burnout rates in Hispanic surgical residents. Design: A three-part cross-sectional survey was distributed to Hispanic surgical residents at the University of Puerto Rico Medical Science Campus. The survey consisted of demographic information, the General Health Questionnaire-12 (GHQ-12), and the Maslach Burnout Inventory (MBI) questionnaire. Descriptive statistics and pairwise correlations were performed to compare groups and responses. Setting: The study took place at the University of Puerto Rico Medical Science Campus, particularly at the external clinics of the medical sciences campus ('ASEM'). Participants: Surgical residents from surgical programs including Orthopaedic surgery, urology, otolaryngology, general surgery, ophthalmology, obstetrics-gynecology, and maxillofacial surgery from the University of Puerto Rico –Medical Sciences Campus. A total of 95 Hispanic surgical residents completed all three sections of the questionnaire (Response Rate = 85%, 95/112). Results: A total of 95/112 (85%) residents completed all three sections of the questionnaire, with 64.2% (61/95) meeting the criteria for burnout. The average age of residents was 30 years, and 37% were female. Residents reported working an average of 67.6 hours a week. The GHQ-12 indicated that 29.5% of residents reported significant psychiatric morbidity. Conclusion: Burnout rates in Hispanic surgical residents were found to be higher compared to burnout rates in non-Hispanic physicians. Earlier stages of residency are associated with higher rates of burnout. In addition, increased work hours and sleep deprivation were associated with higher rates of burnout. However, no correlation was found between marital status, debt level, age, sex, and burnout rates. Psychiatric morbidity (GHQ-12 scale) was associated with higher burnout rates.