Permeability of the small intestine to substances of different molecular weight

Authors:
  • CLC. A. Loehry
    C. A. Loehry
  • AAA. T. R. Axon
    A. T. R. Axon
  • PHP. J. Hilton
    P. J. Hilton
  • RHR. C. Hider
    R. C. Hider
  • BCB. Creamer
    B. Creamer
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Abstract
The permeability of the rabbit small intestine has been studied by measuring the plasma clearances of water-soluble molecules over the molecular weight range 60-33,000. An inverse relationship has been demonstrated between permeability and molecular weight. The significance of these findings in relation to current concepts of the `pore hypotheses' is discussed, and the possible physiological and pathological implications are considered.