In vitro studies toward noninvasive glucose monitoring with optical coherence tomography

We use optical coherence tomography (OCT) to measure glucose-induced changes in Intralipid and in mouse skin samples in vitro. Mouse skin samples are cultured in a ${\text{CO}}_{\text{2}}$ incubator before measurements are made with different amounts of added glucose concentrations. The results show that the glucose-induced changes in the OCT slope value vary between $20\%\text{\hspace{0.17em} and \hspace{0.17em}}52\%∕30\mathrm{mM}$ glucose in different mouse skin samples. This change is much larger than the change in $2\%$ Intralipid $\left(2.1\%/30\text{\hspace{0.17em} mM}\right)$ and in $5\%$ Intralipid $(0.86\%∕30\mathrm{mM})$. Hence the results show that OCT has potential to monitor glucose-induced changes in tissues in vitro.