Radiolabeled imaging agents for Alzheimer's disease
Authors:
Open Access
- 20 September 2023
- journal article
- review article
- Published by Wiley in iRADIOLOGY
- Vol. 2 (1) , 80-95
Abstract
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder with long preclinical and prodromal phases in older people. Molecular imaging is a promising approach for noninvasive in vivo identification and tracking pathophysiological changes. In particular, nuclear neuroimaging in AD has extended beyond traditional evaluation of brain perfusion and glucose metabolism, and has achieved substantial progress over the past 2 decades. To gain a comprehensive understanding of nuclear neuroimaging with different targets in the brain, this review provides an overview of the literature on the current status and recent progress of the development of radioligands for definitive and differential diagnosis of AD.Keywords
This publication has 68 references indexed in Scilit:
- Clinical Validation of 18F-AZD4694, an Amyloid-β–Specific PET RadioligandJournal of Nuclear Medicine, 2012
- 18F-Labeled Phenyldiazenyl Benzothiazole for in Vivo Imaging of Neurofibrillary Tangles in Alzheimer's Disease BrainsACS Medicinal Chemistry Letters, 2011
- [18F]Fluoroazabenzoxazoles as potential amyloid plaque PET tracers: synthesis and in vivo evaluation in rhesus monkeyNuclear Medicine and Biology, 2011
- Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brainsMedChemComm, 2011
- Synthesis and Evaluation of Novel Chalcone Derivatives with 99mTc/Re Complexes as Potential Probes for Detection of β-Amyloid PlaquesACS Chemical Neuroscience, 2010
- Preclinical Properties of 18F-AV-45: A PET Agent for Aβ Plaques in the BrainJournal of Nuclear Medicine, 2009
- Whole-Body Biodistribution and Radiation Dosimetry of 18F-GE067: A Radioligand for In Vivo Brain Amyloid ImagingJournal of Nuclear Medicine, 2009
- Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging AgentsJournal of Medicinal Chemistry, 2003
- Dynamic visualization of a joint-specific autoimmune response through positron emission tomographyNature Immunology, 2002
- Synthesis of N‐(11C) methyl, N‐(methyl‐1 propyl), (chloro‐2 phenyl)‐1 isoquinoleine carboxamide‐3 (PK 11195): A new ligand for peripheral benzodiazepine receptorsJournal of Labelled Compounds and Radiopharmaceuticals, 1984