A Naturally Occurring Novel Reassortant Strain of Infectious Bursal Disease Virus from Quails

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Abstract
Infectious bursal disease virus (IBDV) primarily triggers severe immunosuppression in birds and has resulted in substantial economic losses to the poultry industry globally. Here, a novel naturally reassortant IBDV strain, designated IBDV_G3, was isolated from quails during a disease outbreak in Jiangsu Province, China. Genome sequencing revealed that IBDV_G3 carried segment A derived from the serotype-2-related A0 lineage, while segment B clustered within the B1a classical-like lineage, and this genomic constellation was further confirmed in the original uncultured quail tissues. IBDV_G3 replicated efficiently in LMH cells without prior adaptation, and its VP2 was recognized by the serotype 1 VP2-specific monoclonal antibody 5G10. These findings suggest that quails may harbor reassortant IBDV strains and that the quail–chicken interface warrants continuous surveillance for IBDV reassortment and evolutionary variation.
Funding Information
  • National Natural Science Foundation of China (32673817)
  • Higher Education Discipline Innovation Project (D18007)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions

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