Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future
- 21 September 2010
- journal article
- Published by Springer Nature in Nature Medicine
- Vol. 16 (11) , 1223-1226
Abstract
Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease represent a crucial and exponentially increasing challenge to health care systems throughout the world. There is an urgent need for effective treatments that will both delay their onset and slow their inexorable progression. Many obstacles stand in the way of realizing these goals. It is expected that future advances will have a major impact on how and when the diagnosis will be made. It is hoped that these will eventually make it possible to initiate effective disease-modifying therapies long before the neurodegenerative process becomes established and symptomatic.Keywords
This publication has 51 references indexed in Scilit:
- Genetic Animal Models of Parkinson's DiseaseNeuron, 2010
- Probing the Biology of Alzheimer's Disease in MiceNeuron, 2010
- Clinical core of the Alzheimer's disease neuroimaging initiative: Progress and plansAlzheimer's & Dementia, 2010
- Animal models of amyloid‐β‐related pathologies in Alzheimer’s diseaseThe FEBS Journal, 2010
- Chipping away at diagnostics for neurodegenerative diseasesNeurobiology of Disease, 2009
- Washout and delayed start designs for identifying disease modifying effects in slowly progressive diseases using disease progression analysisPharmaceutical Statistics, 2008
- A randomized, double‐blind, placebo‐controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson's disease (the ADAGIO study): Rationale, design, and baseline characteristicsMovement Disorders, 2008
- Olfactory loss may be a first sign of idiopathic Parkinson's diseaseMovement Disorders, 2007
- Looking Backward to Move Forward: Early Detection of Neurodegenerative DisordersScience, 2003
- Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL‐PET studyAnnals of Neurology, 2003