Palytoxin acidifies chick cardiac cells and activates the Na+/H+ antiporter
Authors:
- Paul VignePVPaul Vigne
- Jean-Philippe BreittmayerJBJean-Philippe Breittmayer
- 7 May 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 264 (1) , 63-66
Abstract
The cardiotoxic action of palytoxin was investigated using embryonic chick ventricular cells. Under normal ionic conditions, palytoxin produced an intracellular acidification which is partially compensated for by the Na+/H+ antiporter thereby leading to an increased rate of ethylisopropylami‐loride‐sensitive 22Na+ uptake. Under depolarizing membrane conditions, palytoxin produced a cellular acidification, a cellular alkalinization or no change in intracellular pH depending on the value of the extracellular pH. We propose that palytoxin acidifies cardiac cells by opening preexisting H+ conducting pathways in the plasma membrane.Keywords
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