Anti-D immune globulin: protecting platelets at a cost

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Open Access

1 September 2005

journal article
Published by American Society of Hematology in Blood

Vol. 106 (5) , 1510
DOI:10.1182/blood-2005-06-2386

Abstract

Sixcasesofdisseminatedintravascularcoagulationafterintravenousadministra- tionofanti-Dimmuneglobulinraiseadditionalconcernaboutintravascularhemo- lysisanddemonstratetheimportanceofpostmarketingdrugsurveillance. relatedrenalinsufficiency.Itwasonlyamatterof timebeforetheothershoedroppedandDICwas recognizedasaconsequenceofintravascular hemolysis.Inhercurrentpaper,Gainesidenti- fies6patientswithfindingsthataresuggestiveof DICassociatedwithhemoglobinemiaand/or hemoglobinuriafollowingintravenousadminis- trationofanti-Dimmuneglobulin.The5 adultsdied;onlythe12-year-oldboyrecov- ered.Theusualproblemsassociatedwith postmarketingsurveillance,suchasnon- uniformdatacollection,variableconsider-

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This publication has 1 reference indexed in Scilit:

Acute onset hemoglobinemia and/or hemoglobinuria and sequelae following Rho(D) immune globulin intravenous administration in immune thrombocytopenic purpura patients
Blood, 2000