Interferon beta-1a for the maintenance of remission in patients with Crohn's disease: results of a phase II dose-finding study
Open Access
- 20 March 2009
- journal article
- research article
- Published by Springer Nature in BMC Gastroenterology
- Vol. 9 (1) , 22
Abstract
Crohn's disease (CD) and multiple sclerosis (MS) share common pathogenic processes. Interferon (IFN) beta-1a is effective and generally well tolerated in patients with MS and has been shown to down-regulate the expression of interleukin-12, a cytokine that is thought to be involved in mucosal degeneration in CD. IFN beta-1a therefore offers promise as a treatment for CD.Keywords
This publication has 31 references indexed in Scilit:
- Clinical trial: a multicentre, randomized, double‐blind, placebo‐controlled, dose‐finding, phase II study of subcutaneous interferon‐β‐1a in moderately active ulcerative colitisAlimentary Pharmacology & Therapeutics, 2008
- Successful Treatment of Steroid Refractory Active Ulcerative Colitis with Natural Interferon-β - an Open Long-Term TrialZeitschrift für Gastroenterologie, 2007
- A case of exacerbation of ulcerative colitis induced by combination therapy with PEG-interferon α-2b and ribavirinGut, 2006
- European evidence based consensus on the diagnosis and management of Crohn’s disease: current managementGut, 2006
- European evidence based consensus on the diagnosis and management of Crohn’s disease: special situationsGut, 2006
- European evidence based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosisGut, 2006
- Interferon-β-1a for the Treatment of Steroid-Refractory Ulcerative Colitis: A Randomized, Double-Blind, Placebo-Controlled TrialClinical Gastroenterology and Hepatology, 2005
- Interferon β-1a in ulcerative colitis: a placebo controlled, randomised, dose escalating studyGut, 2003
- Effects of IL-12 and Antibodies to IL-12 on Established Granulomatous Colitis in MiceAnnals of the New York Academy of Sciences, 1996
- Prospective evaluation of interferon-α in treatment of chronic active Crohn's diseaseDigestive Diseases and Sciences, 1995