Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
Authors:
- Songnian LinSLSongnian Lin
- Matthew LombardoMLMatthew Lombardo
- Sunita MalkaniSMSunita Malkani
- Jeffrey J. HaleJHJeffrey J. Hale
- Sander G. MillsSMSander G. Mills
- Kevin ChapmanKCKevin Chapman
- James E. ThompsonJTJames E. Thompson
- Wen Xiao ZhangWZWen Xiao Zhang
- Ruixiu WangRWRuixiu Wang
- Rose M. CubbonRCRose M. Cubbon
- Edward A. O’nEillEOEdward A. O’nEill
- Silvi LuellSLSilvi Luell
- 1 June 2009
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 19 (12) , 3238-3242
Abstract
No abstract availableKeywords
This publication has 18 references indexed in Scilit:
- Recent advances of TNF-α antagonists in rheumatoid arthritis and chronic heart failureExpert Opinion on Biological Therapy, 2007
- Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)Journal of Medicinal Chemistry, 2007
- MAPKAP Kinase 2-Deficient Mice Are Resistant to Collagen-Induced ArthritisThe Journal of Immunology, 2006
- MAP Kinase p38Inhibitors: Clinical Results and an Intimate Look at Their Interactions with p38α ProteinCurrent Medicinal Chemistry, 2005
- Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)Bioorganic & Medicinal Chemistry Letters, 2005
- New Drugs for Rheumatoid ArthritisNew England Journal of Medicine, 2004
- MK2 Targets AU-rich Elements and Regulates Biosynthesis of Tumor Necrosis Factor and Interleukin-6 Independently at Different Post-transcriptional LevelsJournal of Biological Chemistry, 2002
- MAP KinasesChemical Reviews, 2001
- MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesisNature Cell Biology, 1999
- The Future Role of Anti-Tumour Necrosis Factor (TNF) Products in the Treatment of Rheumatoid ArthritisDrugs, 1998