Large-scale cellular-resolution imaging of neural activity in freely behaving mice
Authors:
- K.A. BoldingKBK.A. Bolding
- Y. CohenYCY. Cohen
- W.A. LibertiWLW.A. Liberti
Preprint
Abstract
Miniaturized microscopes for head-mounted fluorescence imaging are powerful tools for visualizing neural activity during naturalistic behaviors, but the restricted field of view of first-generation ‘miniscopes’ limits the size of neural populations accessible for imaging. Here we describe a novel miniaturized mesoscope offering cellular-resolution imaging over areas spanning several millimeters in freely moving mice. This system enables comprehensive visualization of activity across entire brain regions or interactions across areas.Keywords
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