Multiclass Classification of Sarcopenia Severity in Korean Adults Using Machine Learning and Model Fusion Approaches

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Abstract
This study presents a unified machine learning strategy for identifying various degrees of sarcopenia severity in older adults. The approach combines three optimized algorithms (Random Forest, Gradient Boosting, and Multilayer Perceptron) into a stacked ensemble model, which is assessed with clinical data. A thorough data preparation process involved synthetic minority oversampling to ensure class balance and a dual approach to feature selection using Least Absolute Shrinkage and Selection Operator regression and Random Forest importance. The integrated model achieved remarkable performance with an accuracy of 96.99%, an F1 score of 0.9449, and a Cohen’s Kappa coefficient of 0.9738 while also demonstrating excellent calibration (Brier Score: 0.0125). Interpretability analysis through SHapley Additive exPlanations values identified appendicular skeletal muscle mass, body weight, and functional performance metrics as the most significant predictors, enhancing clinical relevance. The ensemble approach showed superior generalization across all sarcopenia classes compared to individual models. Although limited by dataset representativeness and the use of conventional multiclass classification techniques, the framework shows considerable promise for non-invasive sarcopenia risk assessments and exemplifies the value of interpretable artificial intelligence in geriatric healthcare.
Funding Information
  • Gachon University Research Fund (GCU-202307760001, NRF-2022S1A5C2A07090938)
  • Ministry of Education of the Republic of Korea (GCU-202307760001, NRF-2022S1A5C2A07090938)
  • National Research Foundation of Korea (GCU-202307760001, NRF-2022S1A5C2A07090938)

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