Physiological role for amyloid precursor protein in adult experience-dependent plasticity
- 27 June 2016
- journal article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 113 (28) , 7912-7917
Abstract
Significance: Amyloid precursor protein (APP) has long been implicated in Alzheimer’s disease, but its normal physiological role has only recently come to light. Here we demonstrate that APP plays a key role in axonal pruning after experience-dependent plasticity in the adult. Furthermore, we show that APP operates in a cell-autonomous fashion in the cortex to induce axonal pruning after sensory loss. APP is therefore important for the normal process of adult cortical plasticity through its role in the sculpting of axonal arbors.Keywords
Funding Information
- HHS | NIH | National Institute of Neurological Disorders and Stroke (NS089683)
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