Mini-review: antibody therapeutics targeting G protein-coupled receptors and ion channels
Open Access
- 8 December 2020
- journal article
- review article
- Published by Oxford University Press (OUP) in Antibody Therapeutics
- Vol. 3 (4) , 257-264
Abstract
Antibodies are now well established as therapeutics with many additional advantages over small molecules and peptides relative to their selectivity, bioavailability, half-life and effector function. Major classes of membrane-associated protein targets include G protein-coupled receptors (GPCRs) and ion channels that are linked to a wide range of disease indications across all therapeutic areas. This mini-review summarizes the antibody target landscape for both GPCRs and ion channels as well as current progress in the respective research and development pipelines with some example case studies highlighted from clinical studies, including those being evaluated for the treatment of symptoms in COVID-19 infection.Keywords
This publication has 30 references indexed in Scilit:
- A Sialylated Voltage-Dependent Ca2+ Channel Binds Hemagglutinin and Mediates Influenza A Virus Entry into Mammalian CellsCell Host & Microbe, 2018
- Trends in GPCR drug discovery: new agents, targets and indicationsNature Reviews Drug Discovery, 2017
- Engineering Antibody Reactivity for Efficient Derivatization to Generate NaV1.7 Inhibitory GpTx-1 Peptide–Antibody ConjugatesACS Chemical Biology, 2017
- Opportunities for therapeutic antibodies directed at G-protein-coupled receptorsNature Reviews Drug Discovery, 2017
- Development of therapeutic antibodies to G protein-coupled receptors and ion channels: Opportunities, challenges and their therapeutic potential in respiratory diseasesPharmacology & Therapeutics, 2017
- Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals?Viruses, 2015
- Discovery of Functional Antibodies Targeting Ion ChannelsSLAS Discovery, 2015
- An overview of the diverse roles of G-protein coupled receptors (GPCRs) in the pathophysiology of various human diseasesBiotechnology Advances, 2013
- Therapeutic antibodies directed at G protein-coupled receptorsmAbs, 2010
- CRAC channels and Ca2+ signaling in mast cellsImmunological Reviews, 2009