Antifungal resistance, combinations and pipeline: oh my!
Authors:
Open Access
- 9 November 2023
- journal article
- review article
- Published by BioExcel in Drugs in Context
- Vol. 12, 1-23
Abstract
The purpose of this review is to discuss resistance mechanisms and challenges with currently available agents, provide evidence for combination therapy, and evaluate the newly available and upcoming antifungal agents and their proposed place in the treatment of challenging fungal infections.Keywords
This publication has 164 references indexed in Scilit:
- Loss of Mitochondrial Functions Associated with Azole Resistance in Candida glabrata Results in Enhanced Virulence in MiceAntimicrobial Agents and Chemotherapy, 2011
- A Clinical Isolate of Candida albicans with Mutations in ERG11 (Encoding Sterol 14α-Demethylase) and ERG5 (Encoding C22 Desaturase) Is Cross Resistant to Azoles and Amphotericin BAntimicrobial Agents and Chemotherapy, 2010
- Transcriptional Regulation of Chitin Synthases by Calcineurin Controls Paradoxical Growth of Aspergillus fumigatus in Response to CaspofunginAntimicrobial Agents and Chemotherapy, 2010
- Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of AmericaClinical Infectious Diseases, 2010
- Fungal PDR transporters: Phylogeny, topology, motifs and functionFungal Genetics and Biology, 2010
- Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious diseaseProceedings of the National Academy of Sciences, 2009
- Correlating Echinocandin MIC and Kinetic Inhibition of fks1 Mutant Glucan Synthases for Candida albicans : Implications for Interpretive BreakpointsAntimicrobial Agents and Chemotherapy, 2009
- A Naturally Occurring Proline-to-Alanine Amino Acid Change in Fks1p in Candida parapsilosis , Candida orthopsilosis , and Candida metapsilosis Accounts for Reduced Echinocandin SusceptibilityAntimicrobial Agents and Chemotherapy, 2008
- Potential Basis for Amphotericin B Resistance in Aspergillus terreusAntimicrobial Agents and Chemotherapy, 2008
- Aneuploidy and Isochromosome Formation in Drug-Resistant Candida albicansScience, 2006