Neuroleptic 4-aryltetrahydropyrrolo[3,4-b]indoles

Authors:
  • WWWillard M. Welch
    Willard M. Welch
  • CHCharles A. Harbert
    Charles A. Harbert
  • AWAlbert Weissman
    Albert Weissman
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Abstract
7-Fluoro-4-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-1,2,3,4-tetrahydropyrrolo[3,4-b]indole displayed neuroleptic-like activity in an animal model approximately equipotent with that of chlorpromazine but was of substantially greater duration of action. Structure-activity relationships of the series are discussed.