The effect of short-term low-dose cyclosporin on renal function and blood pressure in patients with psoriasis

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Abstract
The effect of short‐term (mean 2‐4 months), low‐dose (5 mg/kg) cyciosporin A (CyA) on renal function and blood pressure was studied in eight patients with psoriasis. Studies were undertaken before, during and after treatment. Glomerular filtration rate (GHR) post‐treatment was significantly higher than pretreatment or during treatment (pre. 119±7: during, 113±9: post. 133±11 ml/min per 1.73 m2: pre vs. during. NS: during vs. post. PP2). There was no change in the urinary excretion of either albumin or the enzymes N‐acetyl‐glucosaminidase. lactate dehydrogenase. alanine aminopeptidase and alkaline phosphatase. There was a decrease in exchangeable sodium which persisted post‐treatment (pre. 56±3; during. 49±3; post. 49±3 mmol/kgLBM: pre vs. during. P=0.07: during vs. post. NS: pre vs. post. P=0.06). Blood pressure assessed as either a single reading, or the mean of a 24 h ambulatory recording, increased during treatment (single reading: pre, 113/73; during. 126/83; post. 114/70 mmHg: mean 24 h: pre, 114/71: during. 123/76: post. 120/72 mmHg). Thus, short‐term use of CyA at a dose of 5 mg/kg for the treatment of psoriasis is associated with a significant increase in blood pressure, but only a transient mild reduction in GFR, which did not reach significance.

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