Mammalian tracheal development and reconstruction: insights from in vivo and in vitro studies
Open Access
- 1 July 2021
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 148 (13)
Abstract
The trachea delivers inhaled air into the lungs for gas exchange. Anomalies in tracheal development can result in life-threatening malformations, such as tracheoesophageal fistula and tracheomalacia. Given the limitations of current therapeutic approaches, development of technologies for the reconstitution of a three-dimensional trachea from stem cells is urgently required. Recently, single-cell sequencing technologies and quantitative analyses from cell to tissue scale have been employed to decipher the cellular basis of tracheal morphogenesis. In this Review, recent advances in mammalian tracheal development and the generation of tracheal tissues from pluripotent stem cells are summarized.Keywords
Funding Information
- Ministry of Education, Culture, Sports, Science and Technology
- Takeda Science Foundation
- Uehara Memorial Foundation
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